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165 The degree of their antiviral activity against orthopoxviruses in vitro was dependent on the number of atoms in the alkyl or alkoxyalkyl chain, the linker moiety, and the presence of a double bond in the alkoxyalkyl chains linked to the phosphonate moiety of CDV or other nucleoside phosphonates148,149,166 HDP-CDV 16 and ODE-CDV 17, obtained by esteri cation of CDV with 3-hexadecyloxy-1-propanol and 3-octadecyloxy-1-ethanol, respectively, signi cantly enhanced both antiviral potency and selective indices over the parent compound in cell cultures148 150, 166 Importantly, the potency against variola was also increased by more than 200-fold with the alkoxyalkyl prodrugs167 Cellular uptake of 14C-labeled HDP-CDV was many folds greater than that observed with 14C-labeled CDV in human lung.

; Atomically increment the memory location at [R1] ; Return the original memory contents in R0 1 LockedInc: 2 LDREX 3 ADD 4 STREX 5 CMP 6 BNE

The information of positions and distances gathered by a node and the available processor resources also restrict the choice of what method to used. Table 11.3 summarizes and compares the main characteristics of the position computation methods explained in this section.

Line 2 reads the original value of the memory counter and places the monitor into the Exclusive Access state. Line 3 increments the value.

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33 Yokosawa, N; Kubota, T; Fujii, N Poor induction of interferon-induced 20 -50 -oligoadenylate synthetase (2-5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT1a Achives Virol 1998, 143, 1985 1992 34 Young, D F; Didcock, L; Goodbourn, S; Randall, R E Paramyxoviridae use distinct virus-speci c mechanisms to circumvent the interferon response Virology 2000, 269, 383 390 35 Komatsu, T; Takeuchi, K; Yokoo, J; Tanaka, Y; Gotoh, B Sendai virus blocks alpha interferon signaling to signal transducers and activators of transcription J Virol 2000, 74, 2477 2480 36 Najarro, P; Traktman, P; Lewis, J A Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation J Virol 2001, 75, 3185 3196 37 Gale, M J; Korth, M J; Tang, N M; Tan, S L; Hopkins, D.

11.4 LOCALIZATION ALGORITHM The localization algorithm is the main component of a localization system. This component determines how the information of distances and positions will be manipulated in order to allow most or all the nodes of the WSN to estimate their positions. The localization algorithms can be classi ed into some categories: r Distributed or Centralized Position Computation. The positions of the nodes can be computed in a distributed way by the network nodes (selfpositioning) [8, 9, 34] or by a single central node (e.g., a more powerful node, the sink node remote positioning) [5, 46]. r With or Without an Infrastructure. If there is no need for infrastructure [8, 9] or if there is the need to redesign the previous infrastructure in order to allow the functioning of the localization algorithm (e.g., manual placement of the beacon nodes) [34, 36, 47], r Relative or Absolute Positioning. The computed positions can be related to global coordinates (e.g., latitude, longitude) [9, 34] or related to a node or point of the network [48, 49]. r Indoor or Outdoor Scenarios. If the system is more appropriated for indoors [36, 47] or outdoors [34] scenarios. r One Hop or Multi Hop. If all unknown nodes have direct communication with the beacon nodes [34, 47] or if a multihop communication is needed [8, 9].

Many times in this chapter, the word performance was used to make reference to aspects of quality of the localization systems The following aspects can be used to evaluate this performance: r Mean Error and Consistence This identi es is the mean error of the position estimates and also shows if this mean error is repeated in similar but different scenarios (consistence of the mean) This mean error limits the usage of the localization system to the applications where this level of inaccuracies is acceptable r Communication Cost This identi es the algorithm complexity in terms of packets exchanged It also identi es the cost of the localization system to the sensor network r Number of Settled Nodes This de nes the percentage of network nodes that were able to compute their positions at the end of the localization algorithm.

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